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Journal of Nutrition Vol. 110 No. 1 January 1980, pp. 66-73
Copyright © 1980 by American Society for Nutrition
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The Effects of Vitamin E Depletion and Repletion on Prostaglandin Synthesis in Semitendinosus Muscle of Young Rabbits1

Alvin C. Chan2, C. Eugene Allen and P. Vincent J. Hegarty

Department of Food Science and Nutrition and Department of Animal Science, University of Minnesota, St. Paul, MN 55108

The effects of dietary vitamin E-depletion and repletion on the cyclooxygenase activity was studied in the semitendinosus muscle of rabbits. The prostaglandin (PG) cyclooxygenase system in rabbit semitendinosus muscle was characterized and found to depend on reduced glutathione and 1-epinephrine as cofactors. Skeletal muscle cyclooxygenase generates PGE2 and PGF2{alpha} at a ratio approximately equal to one. Weanling New Zealand white rabbits were fed a vitamin E-deficient diet for 4 to 5 weeks. Controls received 50 mg dl-{alpha}-tocopherol acetate twice weekly. Vitamin E deficiency caused a significant reduction in cyclooxygenase activity but did not change the PGE2/PGF2{alpha} ratio. Oral supplementation of tocopherol acetate promptly returned the cyclooxygenase activity back to the control values within 48 hours. The decreased cyclooxygenase activity explains in part the increased level of arachidonic acid in skeletal muscle phospholipid previously reported in this laboratory. The possible involvement of decreased prostaglandin endoperoxides with platelet aggregation in vitamin E deficiency is discussed.

KEY WORDS: • vitamin E • prostaglandin • semitendinosus • cyclooxygenase activity • rabbits

1 Scientific Journal Series, Paper No. 10,763, Minnesota Agricultural Experiment Station.

2 Present address: Dept. of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2, where reprint requests should be sent.

Manuscript received 20 April 1979.




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