QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vander Tuig, J. G. Articles by Leveille, G. A. Search for Related Content PubMed PubMed Citation Articles by Vander Tuig, J. G. Articles by Leveille, G. A.

Maintenance Energy Requirements and Energy Retention of Young Obese (ob/ob) and Lean Mice Housed at 33° and Fed a High-Carbohydrate or a High-Fat Diet¹

Food Science and Human Nutrition Department, Michigan State University, East Lansing, MI 48824

Maintenance energy requirements were estimated for female obese (ob/ob) and lean littermates housed at 33°. Mice were weaned at 21 days of age and fed either a high-carbohydrate or a high-fat diet at three levels of intake for 21 days. Linear regressions relating changes in total body energy to metabolizable-energy intake were used to estimate maintenance energy requirements. To maintain body energy at 33°, obese and lean mice required approximately 72 and 92 kcal per kg^3/4 per day, respectively. (One kilocalorie equals 4.184 kiloJoules.) Diet did not significantly affect maintenance energy requirements. Lean mice fed either diet and obese mice fed the high-carbohydrate diet retained 61% of the metabolizable energy consumed above the maintenance requirement. But obese mice fed the high-fat diet were more efficient; they retained 81% of the metabolizable energy consumed above maintenance. Lean mice deposited a greater percentage of the metabolizable energy available for gain as protein than did obese mice. As expected, maintenance requirements of lean mice housed at 33° were reduced (approximately 25%) compared with results from an earlier study conducted at 25 to 30°. But maintenance energy requirements of obese mice were not changed when the environmental temperature was increased to 33°. Even though obese mice were more efficient in retaining dietary energy than were lean mice at both temperatures examined, the differences were greater at 25 to 30° than at 33°.

KEY WORDS: • maintenance energy requirement • thermoneutral temperature • energy retention • nitrogen retention • dietary fat • obese (ob/ob) mice

¹ Supported in part by NIH AM 15847 and by a Research Career Development Award KO4 AM 00112 to DRR. Michigan Agricultural Experiment Station Journal Article No. 8958.

² To whom reprint requests should be sent.

Manuscript received 13 April 1979.