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The Effect of Dietary Protein on the Biological Activity of Cholecalciferol and Its Metabolites in the Rachitic Rat¹

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706

Rats maintained on low-protein rachitogenic diets show increased intestinal calcium transport, serum inorganic phosphate and increased endochondral calcification responses to calciferol, 25-hydroxycholecalciferol (25-OH-CC) and 1,25-dihydroxycholecalciferol (1,25-(OH)₂CC). Because enhanced responses are observed with 1,25-dihydroxycholecalciferol as well as its precursors, it is unlikely that the effect of dietary protein is mediated by a change in the calciferol-25-hydroxylase and the 25-hydroxycholecalciferol-1-hydroxylase. Instead, it appears that either metabolism of 1,25-dihydroxycholecalciferol or its activity in the target organs is affected.

KEY WORDS: • vitamin D • intestine • bone • dietary protein • "calcium

¹ This work was supported by a program-project grant No. AM-14881 from the National Institutes of Health and a contract No. EY-76-S-02-1668 from the U.S. Energy Research and Development Administration.

² Recipient of NIH International Fellowship 5-FO5 TW02295-02. Present address: National Institute of Nutrition, Indian Council of Medical Research Hyderabad-500007 (A.P.) India.

³ To whom reprint requests should be sent.

Manuscript received 7 May 1979.