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Journal of Nutrition Vol. 110 No. 1 January 1980, pp. 145-150
Copyright © 1980 by American Society for Nutrition
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Isolation of Factors in Linseed Oil Meal Protective against Chronic Selenosis in Rats1,2,

Ivan S. Palmer, Oscar El Olson, Andrew W. Halverson, Roger Miller and Cecil Smith

Chemistry Department, South Dakota State University, Brookings, SD 57007 Northern Regional Center, USDA, Peoria, IL 61600

Two new cyanogenic glycosides, linustatin and neolinustatin, were isolated from linseed oil meal. Each of the compounds was fed to rats in a corn-based diet at levels of 0.1 and 0.2%. At the 0.2% level, both substances gave significant protection against growth depression caused by 9 ppm selenium as sodium selenite. Both compounds also promoted a significant increase in liver and kidney weight over the selenium control animals. Linustatin and neolinustatin are closely related in structure to linamarin and lotaustralin and were found to be present in linseed oil meal at levels of 0.17 and 0.19%, respectively. Linamarin fed at the level of 0.2% also gave significant protection against growth depression and liver damage. A related cyanogenic glycoside, amygdalin, appeared to give a small but nonsignificant protective response. The isolation of the two new glycosides provides a probable explanation for the protective activity of linseed oil meal against selenium toxicity.

KEY WORDS: • selenium toxicity • linseed oil meal • cyanogenic glycosides • linamarin • amygdalin

1 Published with the approval of the South Dakota Agriculture Experiment Station as Journal Article No. 1639.

2 This work was supported in part by the Science and Education Administration of the U.S. Department of Agriculture under Grant No. 5901-0410-8-0016-0 from the Competitive Research Grants office.

Manuscript received 12 April 1979.




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