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Journal of Nutrition Vol. 11 No. 6 June 1936, pp. 593-597
Copyright © 1936 by American Society for Nutrition
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Changes in the Vaginal Epithelium of the Rat on an Excessive Vitamin A Diet1

T. C. Sherwood, M. A. Brend and E. A. Roper

Department of Anatomy and Physiology, University of Kentucky, Lexington

Carotene in oil given daily for 15 days and representing as many as 3750 international units of vitamin A prevented directly or indirectly a normal vaginal smear picture.

Control rats that had received only the normal diet showed a normal oestrous cycle throughout the investigation.

Control rats given cottonseed oil and corn oil also exhibited a normal vaginal picture as observed by the smear technic.

Carotene in large amounts produced a rapid growth of the epithelium for a period of approximately 30 days. This was indicated by the large number of young nucleated epithelial cells which predominated in the vaginal smears.

1 The carotene used in the present investigation was generously furnished by S. M. A. Corporation, Cleveland, Ohio.

Manuscript received 26 February 1936.




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