QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Percival, S. S. Articles by Schneeman, B. O. Search for Related Content PubMed PubMed Citation Articles by Percival, S. S. Articles by Schneeman, B. O.

Long Term Pancreatic Response to Feeding Heat Damaged Casein in Rats¹

Department of Nutrition, University of California, Davis, California 95616

Rats were fed a heat damaged casein (autoclaved 24 hours, 121°, 2 atm) diet to determine the effect of a poorly digested protein on pancreatic enzyme levels and response to a meal. After 10 days of feeding, the pancreas showed no signs of atrophy, however, chymotrypsin and amylase activities were lower in proportion to body weight. An estimation of secretion during the meal was similar or slightly lower in rats fed heated casein (HC) as compared to the casein diet (C), but a greater level of enzyme activity was found in the intestinal contents of rats fed HC relative to control rats. These results suggest that the turnover of enzymes in the gut is reduced when a less digestible protein is fed, and that the endogenous pancreatic secretions and the dietary protein are not digested and absorbed as well.

KEY WORDS: • pancreas • heat damaged protein • digestive enzymes

¹ Supported in part by Grant No. 542 from the Nutrition Foundation, Inc., New York.

² Present address: Dept. of Food Science, Nutrition & Dietetics, University of Rhode Island, Kingston, Rhode Island 02881.

³ To whom requests should be sent.

Manuscript received 1 September 1978.