QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, Y. Articles by Linkswiler, H. M. Search for Related Content PubMed PubMed Citation Articles by Kim, Y. Articles by Linkswiler, H. M.

Effect of Level of Protein Intake on Calcium Metabolism and on Parathyroid and Renal Function in the Adult Human Male¹

Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706

Mechanisms involved in the hypercalciuria caused by high levels of protein intake were investigated. Six healthy males participated in a 20-day metabolic study. During the first 10-day period, all subjects were given a 47 g protein diet and during the second 10-day period, a 142 g protein diet. Calcium, magnesium and phosphorus intakes were kept constant at 515, 320 and 1,110 mg daily, respectively. Urinary calcium was elevated significantly when the protein intake was increased. Glomerular filtration rate and calcium clearance were increased significantly when the high protein diet was fed; the fractional tubular reabsorption of calcium was decreased from 98.4 to 97.4%. Thus, the increase in urinary calcium caused by the high protein diet appears to be due in part to an increase in the filtered load of calcium by the glomeruli and in part to a decrease in calcium reabsorption by the renal tubules. The level of protein intake had no effect on the fasting serum concentrations of parathyroid hormone, total calcium, magnesium or inorganic phosphorus or plasma ultrafiltrable calcium.

KEY WORDS: • high protein diets • urinary calcium • parathyroid hormone • renal function

¹ Supported in part by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and by Grant AM 19290 from the National Institutes of Health, Bethesda. Maryland.

² Send reprint requests to Dr. Hellen Linkswiler. Department of Nutritional Sciences, University of Wisconsin. 1300 Linden Drive, Madison, Wisconsin 53706.

Manuscript received 8 January 1979.

This article has been cited by other articles:

				M. Ferrone and M. Geraci A Review of the Relationship Between Parenteral Nutrition and Metabolic Bone Disease Nutr Clin Pract, June 1, 2007; 22(3): 329 - 339. [Abstract] [Full Text] [PDF]

				P. B Rapuri, J C. Gallagher, and V. Haynatzka Protein intake: effects on bone mineral density and the rate of bone loss in elderly women Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1517 - 1525. [Abstract] [Full Text] [PDF]