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Lysine Deficiency and Voluntary Exercise in the Albino Rat¹

Rutgers, The State University, New Brunswick, New Jersey 08903

The relationship between low dietary protein and voluntary wheel running was investigated by feeding weanling male white rats a natural diet deficient in lysine, by bioassay criterion. Lysine deficient rats ran more than those pair-fed or ad libitum fed the same diet with lysine added. Body composition of active and inactive rats on the three dietary regimens was compared. Of the carcass components, total and percent protein reduction correlated most strongly with running. Control animals matched in growth to the lysine deficient rats showed hyperactivity earlier, but to the same extent as the lysine deficient rats.

KEY WORDS: • lysine deficiency • activity • carcass composition

¹ This paper is based on portions of a dissertation submitted in partial fulfillment of the requirements for the PhD degree, Rutgers University, 1974. The research was supported in part by Research Grant MH10252 to Dr. G. H. Collier, the first author's major advisor and Dr. R. L. Squibb from the National Institute of Mental Health.

² Requests for reprints may be sent to Laura Bolton, Johnson and Johnson Research, U.S. Route 1, North Brunswick, New Jersey 08902.

Manuscript received 16 October 1978.