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Journal of Nutrition Vol. 109 No. 7 July 1979, pp. 1223-1233
Copyright © 1979 by American Society for Nutrition
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The Kinetics of 75Se-Selenium in Relation to Dose and Mode of Administration to Mice1

Jens Carl Hansen and Preben Kristensen

Institute of Hygiene, University of Aarhus, DK-8000 Aarhus C, Denmark

To investigate the effect of selenium in relation to different environmental conditions a study on the kinetics of the element in mice has been carried out on 54 female mice. 75Se (selenite) was administered as a single dose or continuously through drinking water. Different dosage levels were used ranging from "tracer dose" to subtoxic doses. Wholebody counts revealed a biphasic elimination. The first rapid phase was strongly dose-dependent, while the slower second phase of elimination appeared independent of dose as well as mode of administration with a biological half-life of 14.4 ± 3.2 days. Liver, blood, kidney and lungs were found to contain most of the selenium, here also a two-phased elimination was observed. The biological half-lives for elimination calculated during the second phase gave a mean of 10.7 days with a range of 8.7 to 12.5 days. With continuous administration through drinking water a steady state was obtained after 300 to 400 hours of administration according to concentration. A linearity between amount retained at steady state and log concentration in drinking water is indicated. The results on biological half-lives are discussed in relation to previous publications.

KEY WORDS: • selenium • interaction • biological half-life

1 This work is carried out under contract No. 171-77-1 ENV-DK of the E.C. Environmental Research Programme.

Manuscript received 8 June 1978.




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