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Journal of Nutrition Vol. 109 No. 7 July 1979, pp. 1189-1194
Copyright © 1979 by American Society for Nutrition
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The Response of the Acute-Phase Plasma Protein {alpha}2-Macroglobulin to Vitamin A Deficiency in the Rat1

Dian E. Bohannon2, Timothy C. Kiorpes3 and George Wolf4

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Alpha2-macroglobulin ({alpha}2-M) was determined in the sera of vitamin A-deficient and pair-fed control rats. Alpha2-macroglobulin levels were assayed by radial immunodiffusion using a purified standard sample from sera from turpentine-stressed rats. There was no significant increase in the serum level of {alpha}2-M in vitamin A-deficient rats relative to pair-fed controls, indicating that there was no acute response to the stress of the deficiency. When turpentine was injected to elicit an acute response, the serum level of {alpha}2-M rose equally (by almost 100-fold) in both deficient and normal rats. It was concluded that the response to vitamin A deficiency of serum glycoprotein synthesis shows some specificity in that the synthesis of {alpha}2-M in response to stress was not affected by vitamin A, whereas we previously found that levels of {alpha}1-M, which is very similar to {alpha}2-M, decline with vitamin A deficiency.

KEY WORDS: • vitamin A • {alpha}1-macroglobulin • {alpha}2-macroglobulin • rat serum • acute response • turpentine

1 This study was supported in part by National Institutes of Health Grant AM20476.

2 Present address: Connective Tissue Laboratory, Veterans' Administration Outpatient Clinic, 17 Court St., Boston, Massachusetts 02108.

3 Present address: Eye Research Institute of Retina Foundation, 20 Staniford St., Boston, Massachusetts 02108.

4 To whom reprint requests should be addressed.

Manuscript received 14 November 1978.




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