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Effect of Food Toxicants on Voluntary Wheel Running in Rats¹

Bureau of Biological Research, Rutgers University, New Brunswick, New Jersey 08902

Voluntary wheel running in rats in reaction to a dietary deficiency of iron or food toxicants of natural (dioscin) and environmental (cadmium) origins was used to develop a behavioral model by which rapid detection of food contaminants was accomplished following induction of spontaneous activity by techniques of feed restriction. High levels of voluntary wheel running in reference controls were followed by significant depressions in running activity in animals fed the dietary toxicants. Analyses of blood and liver tissues and depressions of testes size confirmed the presence of the insults to metabolism.

KEY WORDS: • induced voluntary exercise • dietary restriction • cadmium • dioscin • iron deficiency

¹ Supported in part by: R. F. Dawson: USPHS Grant HD-03279; and contract DA-49-193-MD-2694, U.S. Army Medical Research and Development Command.

² Present address: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Manuscript received 26 August 1977.