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Vitamin B₆ Dependence of Selenomethionine and Selenite Utilization for Glutathione Peroxidase in the Rat

Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606 Japan

The biological availability of selenium from sodium selenite and selenomethionine for glutathione peroxidase activity was studied. Rats were fed ad libitum for 2 weeks a basal diet deficient in both selenium and vitamin B₆, and then for the subsequent 2 weeks the same diet supplemented with vitamin B₆ (2.5 µg as pyridoxine·HCl/g diet) or selenium (2 µg/g diet) or both. In the presence of vitamin B₆, selenite and selennmethionine increased equally the glutathione peroxidase activity in both the liver and erythrocytes above that of selenium-unsupplemented controls. In the absence of vitamin B₆, selenomethionine was less effective in the liver and ineffective in the erythrocytes while selenite was equally effective in both tissues and was as effective as in the presence of vitamin B₆. These results indicate that selenite selenium is readily available for glutathione peroxidase induction as compared with selenomethionine, and establish that vitamin B₆ is involved in the metabolism of selenomethionine to supply slenium for glutathione peroxidase.

KEY WORDS: • vitamin B₆ • selenite • selenomethionine • glutathione peroxidase

Manuscript received 14 September 1978.