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Amino Acids in Human Blood Plasma after Single Meals of Meat, Oil, Sucrose and Whiskey¹

Department of Nutritional Sciences, University of California, Berkeley, California 94720 and Bruce Lyon Memorial Research Laboratory, Children's Hospital Medical Center, 51st and Grove Streets, Oakland, California 94609

Six healthy men (21 to 38 years; 58 to 80 kg) consumed an adequate diet in a metabolism unit. At 4-day intervals they ingested test meals and venous blood was drawn before and after ingestion at intervals for 8 hours. Test meals were 100, 200, and 300 g of cooked lean meat and quantities of corn oil, sucrose, and whiskey isoenergetic with 200 g of meat. Plasma was analyzed for 20 amino acids. Mean totals of amino acids (micromoles per liter) were maximally elevated at 1 or 2 hours post cibum for all meals and remained above fasting values at 4 hours, with one exception (glucose meal). At 8 hours they were all below fasting values with one exception (whiskey meal). Individual responses varied so much that mean values are misleading. One subject responded well to ingestion of 100 or 200 g of meat but failed to respond to 300 g of meat, oil, or sucrose. Another subject responded well to oil and sucrose, but failed to respond to 100 or 200 g of meat. Mean total fasting amino acid values for all subjects were relatively constant but values for individual subjects ranged from 16% above to 18% below their own fasting means. Ingestion of whiskey invariably resulted in a significant decline in molar ratios for histidine and a significant increase for threonine.

KEY WORDS: • plasma amino acids • blood urea nitrogen • protein test meals

¹ Supported by grants: U.S. Air Force, AF-AFOSR-1336-67: National Science Foundation, GB 8326: NIH, AM10202; NIH, AM17737: NIH, BRSG 5S07RR05467.

² Present address: Bruce Lyon Memorial Research Laboratory, Children's Hospital Medical Center, 51st and Grove Streets, Oakland, California 94609.

³ Present address: Department of Pediatrics, University of Maryland, School of Medicine, Baltimore, Maryland 21201.

⁴ Present address: Department of Agronomy, University of California, Davis, California 95616.

Manuscript received 4 August 1978.