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Journal of Nutrition Vol. 109 No. 4 April 1979, pp. 573-579
Copyright © 1979 by American Society for Nutrition
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In Vivo Intestinal Calcium Transport in Infant Rats: Normal and Growth Retarded1

M. Kabir Younoszai and Fayez K. Ghishan

University of Iowa, Pediatric Gastroenterology Laboratory, Iowa City, Iowa 52242

We compared the in vivo transport of calcium (Ca) in the jejunum + ileum of 1-, 2-, 3-, 4-, and 6-week old rats. In normal rats, net absorption and the estimated bidirectional fluxes of Ca (lumen-to-mucosa and mucosa-to-lumen) normalized for differences in size of the intestine (µmoles/hour per g weight) were similar in the 1-, 2-, and 3-week old rats and significantly lower in the 6-week old than in the younger rats. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have suppressed net absorption and the bidirectional fluxes of calcium in the 4- and 6-week old rats, but to have slightly enhanced net absorption and the bidirectional fluxes in the 1-, 2-, and 3-week old rats. These findings suggested a change in the mechanism(s) for intestinal transport of Ca during maturation. Rate of gain in body weight expressed as g/day increased with age from 1.4 g/day between 1 and 2 weeks, to 6.1 g/day between 4 and 6 weeks of age. There was no correlation between rate of net Ca absorption from the jejunum + ileum and gain in body weight expressed as g/day or as percent per day.

KEY WORDS: • small intestine • infant rats • calcium • transport

1 This study was supported, in part, by Research Grant No. HD08227; Department of Health, Education and Welfare, National Institutes of Child Health and Human Development.

Manuscript received 13 July 1978.




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