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Evidence for an Important Role of Prostaglandins E₂ and F₂ in the Regulation of Zinc Transport in the Rat

Department of Medicine, Veterans Administration Hospital, Sepulveda, California 91343, and University of California, San Fernando Valley Program, Los Angeles, California 90024

The current studies were undertaken to examine the effects of the various prostaglandins (PG) on zinc transport across the rat small intestine. In in vitro studies using everted jejunal sacs, the addition of PGE₂ to the mucosal media increased the transport of ⁶⁵Zn from the mucosal surface to the serosal surface by 54%, whereas the addition of PGF₂ decreased it by 40%. In contrast, addition of PGE₂ to the serosal media decreased ⁶⁵Zn transport from serosa to mucosa by 37% while the addition of PGF₂ increased it by 36%. Our in vivo studies showed that oral administration of PGE₂ caused a 2-fold increase in the ⁶⁵Zn content of rat internal organs whereas PGF₂ decreased it slightly but insignificantly. Pretreatment of rats with indomethacin resulted in a significant decrease in organ ⁶⁵Zn content when compared to control, when the rats were administered ⁶⁵Zn content when compared to control, when the rats were administered ⁶⁵Zn by the oral route. The decrease in organ ⁶⁵Zn content was overcome by the administration of PGE₂. Furthermore, the administration of PGF₂ to indomethacin pretreated rats caused a further and significant decrease in the ⁶⁵Zn content of liver and pancreas—the two organs that have a high zinc uptake. The fact that PG had no effect on the active transport of L-[3-³H]histidine and that PGE₂ and PGF₂ had opposing effects on zinc transport strongly suggest that PGE₂ and PGF₂ act as physiological regulators of zinc transport by the intestinal mucosa, and that their effects are specific.

KEY WORDS: • zinc transport • zinc-binding ligand • prostaglandins • indomethacin • rat intestine • everted intestinal sacs

Manuscript received 13 March 1979.

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