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Interaction of Glucocorticoid and Insulin in the Responses of Rats to Starvation-Refeeding¹

Department of Foods and Nutrition, University of Georgia, Athens, Georgia 30602

Experiments designed to determine whether the role of glucocorticoid (GC) in the induction of the enzyme overshoot response to starvation-refeeding was direct or permissive through insulin were conducted. Intact, adrenalectomized (ADX), and streptozotocin (STREP) treated rats with or without insulin and/or GC replacements were starved for 48 hours and refed a 65% glucose diet for 48 hours. The typical enzyme overshoot response to starvation-refeeding was observed in the intact rats, ADX rats given GC, STREP rats given insulin and ADX-STREP rats given glucocorticoid plus insulin. No overshoot was observed if glucocorticoid was absent whereas a modest increase in enzyme activity could be observed in insulin deficient rats treated with GC.

KEY WORDS: • adrenals • glucocorticoid • pancreas • insulin • starvation-refeeding

¹ Supported in part by USDA Human Nutrition Grant No. 5901-0410-8-0072-0 and by the Georgia Agricultural Experiment Stations under Hatch Project No. H 635.

Manuscript received 14 November 1978.

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