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Effects of Dietary Energy Restriction and Rehabilitation on Growth and Tissue Composition in Growing Rats¹

Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907

Effects of dietary energy restriction and rehabilitation without concomitant protein deficiency were investigated in the rat. Four groups of 12 rats (70 to 80 g) consumed diet C-100 ad libitum for 17 or 31 days, or diet C-50 pair-fed in half the amounts eaten by corresponding littermates in the control group, to reduce energy intake by 50% but provide the same amount of protein and other nutrients. After 28 days energy restriction, 2 groups were rehabilitated for 3 and 13 days by pair-feeding amounts of diet C-100 equal to that consumed by the control groups. Daily weight gains during 17 and 31 days of restriction were 1.9 and 2.5 g versus 4.3 and 4.7 g by the controls; 9.9 and 6.1 g during 3 and 13 days of rehabilitation versus 5.3 g by controls. Liver and muscle weights decreased to 70% of the control values after 17 days of restriction, but increased at the same rate as controls between 17 and 31 days as did the body weights; rehabilitation induced a greater spurt in muscle than liver growth. Significant decreases in lipid concentration were observed in liver after 31 days and in muscle after 17 and 31 days of energy restriction. Rapid accretion of lipid and RNA occurred during rehabilitation. Initial response to energy restriction was one of significant growth retardation; response to prolonged restriction was one of adaptation. During rehabilitation, recovery growth and adaptation indicated efficient utilization of available energy.

KEY WORDS: • energy restriction • rehabilitation • growth • tissue composition • adaptation

¹ From Purdue University Agricultural Experiment Station and Department of Foods and Nutrition, West Lafayette, Indiana 47907. Journal paper No. 6862.

² The data are taken from the doctoral dissertation of the senior author, whose present address is: Section on Biochemistry, Division of Biochemistry. Physiology & Pharmacology, The University of South Dakota School of Medicine, Vermillion, South Dakota 57069.

³ Present address: Department of Nutrition and Food, Auburn University, Auburn, Alabama 36880.

⁴ To whom reprint requests should be directed.

Manuscript received 19 December 1977.