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Journal of Nutrition Vol. 108 No. 8 August 1978, pp. 1260-1265
Copyright © 1978 by American Society for Nutrition
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Effects of Vitamin B-6 Deficiency on the Developing Central Nervous System of the Rat. Myelination1, 2,

Dorothy M. Morré, Avanelle Kirksey3 and Gopal D. Das4

Department of Foods and Nutrition and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907

The effects of different levels of dietary pyridoxine (1.0, 1.2, 1.4, and 20.0 mg/kg diet) fed to dams during growth, gestation and lactation on myelination in progeny were investigated. Degree of myelination at 15 days, postnatally, was determined from closely matched micrographs of the four dietary treatment groups. Electron micrographs showed markedly less myelination in the 1.0 group as compared with the 1.4 and 20.0 groups with the 1.2 group appearing intermediate in the number of myelinated axons. Some myelinated axons of the 1.0 group exhibited an "unusual" appearance of whorls of lamina separated by cytoplasmic space occupied by widely separated lamina. The results indicate that brain development, particularly myelination, was affected by a deficiency of vitamin B-6 prior to and including the period of rapid myelination.

KEY WORDS: • pyridoxine • rat • ultrastructure • myelination

1 Supported in part by USPHS grant NS-1005 and Purdue Research Foundation, 8546-561264, Paper No. 7029 of the Purdue University Agricultural Experiment Station, West Lafayette, Indiana 47907.

2 Work originates from work submitted in partial fulfillment of the requirement for the Doctor of Philosophy.

3 Send reprint requests to: A. Kirksey, Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907.

4 Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

Manuscript received 23 January 1978.




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