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Journal of Nutrition Vol. 108 No. 8 August 1978, pp. 1222-1228
Copyright © 1978 by American Society for Nutrition
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Changes in Rat Pancreatic Protein Synthesis After a Single Feeding with Diets Containing Raw or Heated Soybeans1

Jan Dijkhof and Cees Poort

Laboratory of Histology and Cell Biology, Medical School, State University, Utrecht (2501), 22 Nicolaas Beetsstraat, The Netherlands

The patterns of protein synthesis following the administration of a single meal containing defatted ground soybeans (RSD) or heated defatted ground soybeans (HSD) were compared. A double label method was used so that the determination of the relative rate of synthesis of an enzyme could not be obscured by a possible alteration of the activity or quantity of the enzyme. Rats were given one meal of RSD or HSD and were subsequently killed at different times after the meal. Eight hours after the meal, the relative rate of synthesis of one of the three trypsinogens was substantially increased with RSD feeding, whereas that of the amylases and one chymotrypsinogen were somewhat lower. The synthetic rate of lipase, ribonuclease, proelastase, another chymotrypsinogen and of two trypsinogens was unaffected when feeding RSD is compared to feeding HSD. The relative rate of synthesis of one of the trypsinogens was unaffected 8 hours after RSD feeding, but was increased 16 hours after RSD feeding. Actinomycin D could suppress the effects of RSD feeding on the protein synthetic rate of some, but not of all, secretory proteins.

KEY WORDS: • soybeans • pancreas • protein synthesis • double label • short term feeding • actinomycin D

1 Part of this work was presented at the 8th Symposium of the European Pancreatic Club, Toulouse, France, October, 1975.

Manuscript received 28 November 1977.




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