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Calcium Metabolism, Intestinal Calcium-binding Protein, and Bone Growth of Rats Fed High Protein Diets^{1, 2, 3,}

Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06268

The rat was used as a model for investigating the mechanism by which the consumption of high protein diets causes calciuria. Using a combined balance and kinetics study, calcium (Ca) metabolism was studied in 56-day old male rats which had been consuming a control (18% casein) or a high protein (36% casein) diet for 2, 14, or 28 days. Urine Ca was significantly increased to 1.7 mg/day and 1.1 mg/day in rats which consumed the high protein diet for 2 or 14 days respectively. After 29 days of consuming the high protein diet, urinary Ca excretion was 0.7 mg/day, the same as that of controls. No other criteria of calcium metabolism were significantly affected by the high protein intakes. Intestinal calcium-binding protein activity was not affected by consumption of the 36% casein diet for 7 days, nor was bone mineralization after consumption of this diet for 32 days. Since the rat excretes a low percentage of dietary Ca via the urinary route, it is not a useful model for studying Ca kinetics in protein-induced calciuria.

KEY WORDS: • protein • calcium • calcium-binding protein • bone

¹ Supported in part by U.S. Public Health Service Research Grant DE-04295, and University of Connecticut Research Foundation Grant 5.171-000-22-0109-35-123.

² Presented in part at the meeting of the Federation of American Societies for Experimental Biology, 1976, Federation Proc. 35, 499.

³ Scientific Contribution No. 700, Agricultural Experiment Station, University of Connecticut, Storrs, 06268.

Manuscript received 9 December 1977.

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