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Effects of Diet on Swine Glyceride Lipid Metabolism

Shell Development Company, Biological Sciences Research Center, Modesto, California 95352

Swine were fed equal amounts of isoenergetic-isonitrogenous diets with low-fat or high-fat content. The high-fat diet, as well as starvation, suppressed the synthesis of fatty acid from glucose in adipose tissue. Diet had no effect on adipose tissue enzymes associated with glyceride synthesis; whereas starvation caused all activities expressed per g tissue to decrease. The hepatic enzyme activities associated with glyceride synthesis tended to be greater in swine fed the high-fat diet compared to the low-fat diet. Starvation lowered the hepatic esterification of glycerol-3-phosphate but did not influence other enzymes.

KEY WORDS: • swine • fatty acid synthesis • glyceride synthesis • adipose tissue • liver

¹ Present address: General Foods Corporation, The Technical Center, White Plains, New York 10625.

Manuscript received 3 October 1977.