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Effect of Phosphorus on the Absorption of Calcium and on the Calcium Balance in Man¹

Metabolic Section, Veterans Administration Hospital, Hines, Illinois 60141

The effect of phosphorus on the intestinal absorption of calcium was investigated in man with oral tracer doses of ⁴⁷Ca in control studies during an 800 mg/day phosphorus intake and during a 2,000 mg/day phosphorus intake which was due to the addition of sodium glycerophosphate. The studies were carried out during calcium intake levels of about 200, 800, 1,500, 2,000, and 2,700 mg calcium per day. The plasma levels of ⁴⁷Ca and the urinary and fecal ⁴⁷Ca excretions were assayed. The intestinal absorption of ⁴⁷Ca did not differ significantly in the high phosphorus studies during the 200, 800, and 1,500 mg/day calcium intakes as was demonstrated by the lack of change of the ⁴⁷Ca plasma levels and fecal ⁴⁷Ca excretions. The ⁴⁷Ca absorption during the 2,000 mg/day calcium intake was significantly decreased due to the lower absorption of one of six patients studied and there was no significant difference in calcium absorption during the 2,700 mg/day calcium intake. In all studies the urinary calcium decreased significantly during phosphorus supplementation, except during the 2,700 mg/day calcium intake. The stool calcium did not differ significantly during phosphorus supplementation, except during the low calcium intake. The urinary and fecal phosphorus increased significantly during phosphorus supplementation in all studies while the phosphorus balances increased significantly only during the 2,000 and 2,700 mg/day calcium intakes.

KEY WORDS: • calcium absorption • calcium balance • phosphorus balance

¹ Supported in part by USPHS grant DE-02486 and in part by the National Dairy Council.

Manuscript received 10 June 1976.

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