QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by O’Flaherty, E. J. Articles by McCarty, C. P. Search for Related Content PubMed PubMed Citation Articles by O’Flaherty, E. J. Articles by McCarty, C. P.

Alterations of Rat Adipose Tissue Metabolism Associated with Dietary Chromium Supplementation¹

Kettering Laboratory, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267

Net free fatty acid release from adipose tissue taken from male rats fed a stock diet unsupplemented with chromium was significantly greater than that from adipose tissue taken from chromium-supplemented rats. This enhanced net lipolysis was unaccompanied by any evidence of a compensatory increase in reesterification. Specifically, the glycerokinase-catalyzed direct phosphorylation of glycerol, which might have provided an alternate supply of -glycerophosphate for reesterification in the absence of glycolytic production of -glycerophosphate, was significantly reduced. These animals also showed an abnormal glucose tolerance response. In contrast, male rats fed a purified diet unsupplemented with chromium appeared to be marginally chromium-deficient as judged by a glucose tolerance test but did not show any alterations in adipose tissue metabolism attributable to the adequacy of chromium nutriture.

KEY WORDS: • chromium • nutriture • lipolysis • adipose tissue • glycerokinase

¹ This work was supported by USPHS Grant ES-00159 and by a grant from the General Research Support funds of the College of Medicine, University of Cincinnati.

Manuscript received 2 May 1977.