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The Effect of Chronic Ethanol Ingestion on Myocardial Glucose and Energy Metabolism

Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201

To determine the effect of chronic alcohol ingestion, rats were given 15 or 25% v/v of alcohol in water for a period of 6 months. The activities of some key enzymes involved in the metabolism of glucose, mitochondrial respiratory rates, and efficiency of oxidative phosphorylation were studied in the hearts of alcohol-treated and untreated rats. In the group receiving 15% alcohol, glucose-6-phosphate dehydrogenase (G-6-PDH) was elevated. In rats given 25% alcohol, activities of G-6-PDH, aldolase, and glyceraldehyde phosphate dehydrogenase were elevated but isocitrate dehydrogenase was reduced. Mitochondrial respiratory rates and the efficiency of phosphorylation were depressed in rats given 25% alcohol. Except for mitochondrial oxidation of pyruvate and -ketoglutarate, all biochemical parameters studied were within normal limits a month after alcohol was discontinued.

KEY WORDS: • ethanol ingestion • energy metabolism • glucose metabolism • heart

Manuscript received 20 October 1977.