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Genetic Influence on Zinc Metabolism in Mice¹

United States Department of Agriculture, Agricultural Research Service, Human Nutrition Laboratory, Grand Forks, North Dakota 58201

A previous study resulted in the discovery of a unique, undesignated strain of mice, referred to as SM (Super Mouse), whose progeny exhibited a resistance to dietary zinc deficiency when pups from the strain suckled dams fed a zinc-deficient diet. Examination of the zinc metabolism in these mice demonstrated in the study reported here that SM mice accumulate significantly more zinc during in utero development than do mice of other strains. Adult mice of the SM strain contained significantly more bone zinc than did mice of other strains. Adult SM mice excreted significantly less ⁶⁵Zn than did mice of other strains when the mice were fed a zinc-deficient diet. These observations suggest that SM mice are able to resist periods of zinc-deficiency as a result of the development of highly efficient systems for storing and reabsorbing zinc.

KEY WORDS: • zinc metabolism

¹ This work was supported in part by the USDA Cooperative Agreement No. 12-14-100-11. 178 (61), Amend. 1.

² Department of Biochemistry, University of North Dakota School of Medicine, Grand Forks, North Dakota 58201.

³ Research Chemist, USDA, ARS, Human Nutrition Laboratory, P.O. Box 7166, University Station, Grand Forks, North Dakota 58201.

Manuscript received 18 February 1977.