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Effects of a Prolonged Vitamin E Deficiency in the Rat¹

Department of Biochemical Nutrition, Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, and ^* Washington University, School of Medicine, St. Louis, Missouri 63110

Rats fed a vitamin E-deficient diet containing 10% "stripped" corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected in the E-deficient rats.

KEY WORDS: • vitamin E deficiency • thrombocythemia • anemia • kyphoscoliosis • neuropathy • myopathy • ascorbic acid synthesis

¹ A preliminary report has been presented (Federation Proc. 33, 672, 1974). Supported in part by USPHS Grant NS 11277.

Manuscript received 15 November 1976.

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