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Biological Effects of Feeding Graded Levels of Alkali Treated Soybean Protein Containing Lysinoalanine (N^e-2-[carboxyethyl]-L-lysine) in Sprague-Dawley and Wistar Rats¹

Ralston Purina Company, 900 Checkerboard Square, St. Louis, Missouri 63188

Experiments were conducted to determine if there is a dose-response to graded levels of dietary lysinoalanine (LAL), and whether or not a strain difference exists in the response to LAL by Sprague-Dawley (S/D) and Wistar (WIS) rats with respect to renal cell cytomegaly and other parameters. S/D rats were fed 0, 5%, 10%, 20%, and 30% of an alkali-treated isolated soybean protein (ATSP), which contained 1.0% LAL. The 0 and 30% ATSP diets were also fed to WIS rats. Marked renal cell cytomegaly was seen only in S/D rats fed the 30% ATSP diet. On a scale of 0 to 3 (normal to severe), S/D rats fed the control diet scored 0.3 and those fed 30% ATSP, 1.8. WIS controls scored 0.0 and WIS 30% ATSP, 0.6. At ATSP levels lower than 30%, scores ranged from 0.2 to 0.4, and were not significantly different from those of the controls. Renal calcification was not seen in the soybean control fed rats; however, at the highest ATSP level both WIS and S/D females developed calcification. The strain difference again was marked. WIS rats scored twice as high on a 0 to 3 scale as S/D rats. Feed efficiency and weight gain were reduced at 30% ATSP, but not at lower levels. Blood urea nitrogen, creatinine and renal -glutamyl transpeptidase measured in vitro were not different from controls at any ATSP levels.

KEY WORDS: • lysinoalanine • alkali-treated soybean protein • renal cell cytomegaly • renal calcification

¹ Some of the data in this paper were presented at the 60th annual meeting of the Federation of American Societies for Experimental Biology, Anabeim, Calif., April, 1976, Abstract No. 1613.

Manuscript received 10 June 1976.