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Influence of Prolonged Fasting in the Dog on Glucose Turnover and Blood Metabolites¹

Departments of Food Science and Human Nutrition and Animal Husbandry, Michigan State University, East Lansing, Michigan 48824

Glucose turnover and blood metabolites were measured in eight adult female beagles in the fed state, at 1 day of fasting, and at 7, 14, and 21 days of fasting. Glucose utilization decreased significantly from 1 to 7 days of fasting, but remained constant from 7 to 21 days, while blood ketones and plasma free fatty acids rose significantly during the same period. Plasma alanine, serine, and glycine fell with fasting, with the greatest decrease in alanine levels occurring between 7 to 14 days. Plasma branched chain amino acids rose significantly with fasting. It was concluded that the shifts in plasma metabolites and decreased glucose utilization could be indicative of decreased energy demands of the fasting dogs and/or a shift in substrate utilization with progressive fasting.

KEY WORDS: • glucose utilization • plasma amino acids • blood lactate • blood ketones • fasting • dog

¹ Supported in part by Public Health Service Grants AM 18957 and GM 01818. DRR is the recipient of Career Development Award K04 AM 00112. Michigan Agriculture Experiment Station Journal Article No. 7784.

Manuscript received 27 August 1976.