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Relative Toxicity and Metabolic Effects of Cholecalciferol and 25-Hydroxycholecalciferol in Chicks1,2,

Robert L. Morrissey, Robert M. Cohn, R. N. Empson, Jr., Harry L. Greene, O. David Taunton and Zigmund Z. Ziporin

Radioisotope Division, Letterman Army Institute of Research, Presidio of San Francisco, California 94129

The relative toxicity and metabolic effectiveness of cholecalciferol (CC) and 25-hydroxycholecalciferol (25-HCC) in chicks were evaluated by feeding six graded levels of each and observing gross and microscopic pathology as well as several metabolic parameters of calcium metabolism. Renal tubular calcification was observed when CC was fed at the rate of 10.0 mg/kg of diet and when 25-HCC was fed at the rate of 0.1 mg/kg diet. Thus, 100-fold increase in toxicity results when the hydroxylated form of CC is fed. Both microscopic renal lesions and increased renal calcium and inorganic phosphate concentrations occurred in chicks with normal serum calcium concentrations.

KEY WORDS: • Toxicity • Vitamin D • 25-Hydroxycholecalciferol

1 In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care, of the Institute of Laboratory Animal Resources, National Academy of Sciences—National Research Council.

2 The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Manuscript received 24 May 1976.




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