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Effects of Selenite and Selenomethionine on Glutathione Peroxidase in the Rat¹

Department of Food Science and Technology, University of California, Davis, California 95616

The activity of glutathione (GSH) peroxidase (EC 1.11.1.9) decreased in tissues of rats fed a diet deficient in selenium. A single dose of 300 µg selenium by stomach tube increased GSH peroxidase activity within 48 hours. The effects of selenite and selenomethionine on GSH peroxidase activity were roughly similar. This study provides evidence that selenium from both selenite and selenomethionine is readily available for synthesis of the selenoenzyme GSH peroxidase in rat tissues.

KEY WORDS: • selenium • glutathione peroxidase • selenomethionine • selenite

¹ This research was supported in part by N.I.H. research grant AM06424 from the National Institute of Arthritis, Metabolism and Digestive Diseases and in part by the National Institute of Environmental Health Sciences and the Environmental Protection Agency 2P01ES00628-05A1.

Manuscript received 1 July 1976.

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