QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schneeman, B. O. Articles by Lyman, R. L. Search for Related Content PubMed PubMed Citation Articles by Schneeman, B. O. Articles by Lyman, R. L.

Effect of Dietary Amino Acids, Casein, and Soybean Trypsin Inhibitor on Pancreatic Protein Secretion in Rats¹

Department of Nutritional Sciences, University of California, Berkeley, California 94720

Pancreatic enzyme output in response to various purified diets was studied in rats surgically prepared so that pancreatic secretion could be continuously collected, assayed and returned to the intestine. Intraduodenal infusion of phenylalanine and tryptophan alone did not stimulate secretion. Diets containing phenylalanine, tryptophan, a mixture of amino acids, or hydrolyzed casein, fed intragastrically, evoked a small pancreatic response that was similar to the response to a protein-free diet. Intragastric infusion of a diet containing 18% casein stimulated a large initial secretion of enzyme that remained elevated throughout the 5.5 hour experiment. Addition of soybean trypsin inhibitor (SBTI) to the diet increased the pancreatic response over that due to dietary casein alone. When pancreatic juice was diverted from the intestine, the large pancreatic responses to casein or to casein + SBTI were greatly reduced and the response was similar to that of the protein-free diet.

KEY WORDS: • pancreatic enzymes • dietary protein • trypsin inhibitor

¹ This work was supported by Grant No. AM 16259 from DHEW. National Institutes of Health.

² Supported by Postdoctoral Fellowship No. 5F22 AM01909 from DHEW, National Institutes of Health. Present address: Nutrition Department, University of California, Davis, California 95616. To whom inquiries should be sent.

³ Died December 2, 1975.

Manuscript received 7 June 1976.