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Journal of Nutrition Vol. 107 No. 2 February 1977, pp. 213-220
Copyright © 1977 by American Society for Nutrition
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Effect of Prenatal Protein Deprivation on Fetal and Neonatal Thyroid Morphology in the Rat1

Ruth E. Shrader, Mary M. Hastings-Roberts, Millie I. Ferlatte and Frances J. Zeman2

Department of Nutrition, University of California, Davis, California 95616

Morphogenesis of the thyroid was compared in young of control and protein-deprived rats from day 17 of gestation through the first postpartum day. Examination of histological sections revealed a significant delay in follicle formation and a reduction in gland area, follicle number, colloid space and cell size in the thyroid tissue of fetal and neonatal pups of protein-deprived dams.

KEY WORDS: • protein deficiency • thyroid • development • pregnancy

1 Supported in part by Public Health Service Research Grant No. HD-08499 from the National Institute of Child Health and Human Development.

2 To whom reprint requests should be sent.

Manuscript received 15 March 1976.




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