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Relative Activities of Some Metabolites and Analogs of Cholecalciferol in Stimulation of Tibia Ash Weight in Chicks Otherwise Deprived of Vitamin D

Department of Cell Biology, Roche Research Center, Nutley, New Jersey 07110

Nine metabolites and analogs of cholecalciferol (CC) were tested for ability to increase tibia ash weight in chicks otherwise deprived of vitamin D. All of the compounds promoted bone mineralization in a linear log dose-response relationship. The maximal response obtained for any compound was an approximate doubling in bone ash weight compared to vehicle-treated controls. Relative potencies, based upon the calculated ash weight doubling dose, were as follows: 1,25-(OH)₂-CC = 1-OH-CC > CC > 25-OH-CC > 24R,25-(OH)₂-CC = 1,24R,25-(OH)₃-CC > 5,6-trans-25-OH-CC > 124S,25-(OH)₃-CC > 5,6-trans-CC > 24S,25-(OH)₂-CC.

KEY WORDS: • cholecalciferol • vitamin D • bone ash • vitamin D metabolites • vitamin D analogs

Manuscript received 14 May 1976.