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Effects of Thiamin Deficiency on Acetylcholine Levels and Utilization in vivo in Rat Brain¹

Tennessee Neuropsychiatric Institute and the Departments of Psychology, Pharmacology and Medicine of Vanderbilt University and the Veterans Administration Hospital, Nashville, Tennessee 37217

Cerebral regional acetylcholine (ACh) levels and utilization were studied in vivo in thiamin deficient (TD), pair-fed asymptomatic (PFC) and ad libitum fed control (ALC) rats. ACh levels in the cortex, corpus striatum, midbrain, diencephalon and brainstem of TD rats were comparable to those observed in the control groups. However, ACh utilization was slightly to moderately (10–41%) decreased in cortex, midbrain, diencephalon and brainstem. The decrease was significantly different in the midbrain of TD rats as compared to PFC and ALC rats.

KEY WORDS: • acetylcholine • thiamin deficiency

¹ Supported in part by NIH grants MH-08107 and AA0267-05.

² Address reprint requests to: Tennessee Neuropsychiatric Institute, Cooper Building, Central State Psychiatric Hospital, 1501 Murfreesboro Road, Nashville, Tennessee 37217.

Manuscript received 15 March 1977.