Journal of Nutrition

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Journal of Nutrition Vol. 107 No. 10 October 1977, pp. 1779-1785
Copyright © 1977 by American Society for Nutrition
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Anemia of Lead Intoxication: A Role for Copper1

David S. Klauder2 and Harold G. Petering

Kettering Laboratory, Department of Environmental Health, College of Medicine, University of Cincinnati, 3223 Eden Avenue, Cincinnati, Ohio 45267

Lead-induced anemia in rats, which is of a microcytic, hypochromic type, has been shown to be a result of an interference with the metabolism of copper and iron. In this complex interaction, copper may be the target upon which ingested lead has its antagonistic effect on hematopoiesis. The depressions in hematocrit and hemoglobin levels resulting from exposure to lead may occur secondarily to the effects of a lead-induced copper deficiency on iron mobilization and utilization. The metabolic fault induced by lead is seen in a reduction of serum iron, elevation of serum iron binding capacity, and increase in liver iron, all manifestations of systemic effects related to an interference with copper metabolism. These results relate many of the characteristics of the lead-induced anemia to those found in the copper-deficiency anemia.

KEY WORDS: • copper metabolism • iron metabolism • lead toxicity • lead anemia • copper-iron interaction • copper-lead interaction • iron-lead interaction

1 Reprint requests to University of Cincinnati, Department of Environmental Health, College of Medicine, Kettering Laboratory, 3223 Eden Avenue, Cincinnati, Ohio 45267 (Dr. H. G. Petering).

2 Present Address: Environmental Scientist. Food and Drug Administration (HFS-30), Room 7-71, 5600 Fishers Lane, Rockville, Maryland 20852.

Manuscript received 18 January 1977.




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