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Effect of Fluoride on the Serum Lipids of Guinea Pigs^1,2,

Department of Biochemistry, 227 Millard Hall, University of Minnesota, Minneapolis, Minnesota 55455

The effects of fluoride intake on the serum lipids of guinea pigs were determined in animals provided with either high or low levels of fat in their diet and fluoride in their drinking water. Evidence of the difference in fluoride intake were reflected by serum fluoride contents. The results suggested that, in guinea pigs receiving excess dietary cholesterol, an inadequate fluoride intake is reflected in increased serum cholesterol. Fluoride intake also influenced the serum triglyceride levels, but the direction of the response was dependent on the amount of dietary fat. Serum free fatty acids and phospholipids were not influenced by fluoride intake.

KEY WORDS: • fluoride • cholesterol • triglycerides

¹ Supported by National Institute of Dental Research grant #DE01850.

² Send reprint requests to Dr. Leon Singer, Department of Biochemistry, 227 Millard Hall, University of Minnesota, Minneapolis 55455.

Manuscript received 20 April 1976.