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Comparison of the Binding of Various Bile Acids and Bile Salts in Vitro by Several Types of Fiber¹

The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104

The binding in vitro of the sodium salts of cholic acid, chenodeoxycholic acid, deoxycholic acid, taurocholic acid, taurocheno-deoxycholic acid, taurodeoxycholic acid, glycocholic acid, glycocheno-deoxycholic acid, and glycodeoxycholic acid by alfalfa, bran, cellulose, lignin, and cholestyramine was measured. Cholestyramine bound an average of 81.3% of all the bile acids and salts tested whereas cellulose bound only negligible amounts (1.4%). Of the other substances tested, lignin bound 29.2%, alfalfa, 15.9% and bran, 9.0%. No distinct pattern of binding was discerned. It is therefore apparent that the validity of statements concerning the effect of fiber on bile salt metabolism rests upon the specificity of the composition of the fiber involved and the bile acids or salts tested.

KEY WORDS: • bile salts • bile acids • bile salt binding • fiber

¹ This work was supported in part by USPHS grant HL-03299, and Research Career Award HL-00734 from the National Heart and Lung Institute and grants-in-aid from the National Dairy Council and the National Livestock and Meat Board.

Manuscript received 29 January 1976.

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