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Evidence for a Lack of an Effect of Dietary Fluoride Level on Reproduction in Mice¹

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

The possible essentiality of fluoride for reproduction was studied in female mice fed a low-fluoride (<0.5 ppm F) basal diet for three generations. Reproduction of mice fed this basal diet was the same as when mice were fed the basal diet supplemented with 2 or 100 ppm F. A previous study [Messer et al. (1973) J. Nutr. 103, 1319–1326], utilizing the same diet did result in an impairment of reproduction and the development of an anemic condition. The results of the present study suggest that the apparent essentiality of fluoride previously observed was due to a pharmacological effect of fluoride in improving iron utilization in a diet marginally sufficient in iron. The data do not support the previous claims of an essential role of fluoride in reproduction.

KEY WORDS: • fluoride • copper • iron • reproduction • essentiality • mice

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin-Madison, and in part by a research grant from the Aluminum Company of America. Aluminum Company of Canada. Kennecott Copper Corporation, Monsanto Chemical Company. Ormet Corporation, Eastalco Aluminum Company. Stauffer Chemical Company, Reynolds Metals Company, Kaiser Aluminum and Chemical Corporation. Anaconda Aluminum Company. Martin Martetta, U.S. Steel Corporation, Intalco Aluminum Corporation, National Southwire Aluminum Company, and in part by U.S. Public Health Service Grant AM-15521.

Manuscript received 22 December 1975.