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Utilization of L-Methionine Sulfoxide, L-Methionine Sulfone and Cysteic Acid by the Weanling Rat^1,2,3,

Department of Nutrition and Food Science, University of Toronto, Toronto, Canada, M5S 1A1 and Food Research Institute, Agriculture Canada, Research Branch, Ottawa, Canada, K1A OC6

Three experiments were conducted to test the ability of weanling rats to utilize the oxidized forms of the sulfur amino acids methionine and cysteine for growth. In the first two experiments, diets were fed which contained graded levels of methionine, methionine sulfoxide and methionine sulfone. The third experiment included a comparison of two dietary levels of cysteine and cysteic acid. The 2 week weight gain and food consumption data indicated that methionine sulfoxide was utilized for growth with only 60% of the efficiency of that achieved by rats fed methionine. Methionine sulfone was not utilized for growth. Analysis of plasma sulfur amino acids showed that the rat has a limited capacity to utilize methionine sulfoxide by effecting its reduction to methionine. Cysteic acid did not support weight gain. This amino acid appeared to be rapidly catabolized to taurine. It was concluded that methionine sulfone and cysteic acid cannot be utilized by the weanling rat. Methionine sulfoxide cannot fully meet the dietary requirement of the rat for methionine because of its limited capacity to reduce this amino acid.

KEY WORDS: • methionine sulfone • methionine sulfoxide • cysteic acid • weanling rats • plasma level • growth

¹ Publication No. 259 from the Food Research Institute.

² Address reprint requests to Dr. G. H. Anderson.

³ Supported by Extramural Research Grant 6601 from Agriculture Canada.

Manuscript received 22 December 1975.

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