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Rat Strain Differences in Cyclic-AMP Levels in Liver and Epididymal Fat Pad Tissue as Influenced by Glucagon¹

NUSC, University of Maryland, College Park, Maryland 20742, and Nutrition Institute, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705

A glucagon-saline solution (0.1 ml, 10^-7 mole/100 g body weight) was injected via the portal vein into nonfasted Wistar and carbohydrate-sensitive BHE rats. Levels of liver and epididymal fat pad cyclic-AMP were observed after 6 and 24 minutes. When compared to sham injected rats at 6 minutes, glucagon injected rats of both strains had twice the level of cyclic-AMP in liver and fat pad tissue. By 24 minutes, the cyclic-AMP levels of the Wistar rats had decreased to those observed in their sham injected counterparts, and the concentration of liver cyclic-AMP in both sham injected and glucagon injected BHE rats had decreased to levels significantly below those observed in the Wistar rats. This observation suggests that a lipolytic-lipogenic imbalance may reside in the livers of rats of the BHE strain.

KEY WORDS: • BHE strain • cyclic-AMP • carbohydrate-sensitive • glucagon

¹ From a dissertation to be submitted to the Graduate School, University of Maryland, by Elizabeth B. Spannhake, in partial fulfillment of the requirements for the M.S. degree in Nutritional Sciences.

Manuscript received 17 December 1975.