QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Delorme, C. B. Articles by Lupien, P.-J. Search for Related Content PubMed PubMed Citation Articles by Delorme, C. B. Articles by Lupien, P.-J.

The Effect of a Long-Term Excess of Pyridoxine on the Fatty Acid Composition of the Major Phospholipids in the Rat¹

Centre de recherches sur les maladies lipidiques, and Centre de recherches en nutrition, Département de biochimie, Faculté de médecine, Université Laval, Québec, Qué., Canada G1K 7P4

The effect of a long-term excess of pyridoxine on the fatty acid spectrum of phosphatidylcholine, lysophosphatidylcholine and phosphatidylethanolamine of liver, plasma and kidneys in rats was studied to determine whether this response might be opposite to that observed during a deficiency. As a function of time, the fatty acid composition of the phospholipids generally changed similarly in both the control group and the pyridoxine-treated group. Though differences did occur between the two groups, particularly on day 14 of the treatment, they generally disappeared by day 22. We therefore attributed the major part of the changes occurring in the pyridoxine-treated rats to the age or development of the rats rather than to the pyridoxine treatment itself. In general, the proportion of arachidonic acid increased with time in the phospholipids of both groups while that of linoleic acid decreased. The magnitude of these changes and the proportion of the different fatty acids in the various phospholipids were not uniform from one phospholipid to another or from one tissue to another. Possible mechanisms were discussed.

KEY WORDS: • pyridoxine excess • vitamin B₆ • phospholipids • fatty acids

¹ This study was supported by a grant from the Medical Research Council of Canada.

² Present address: Centre de recherches en nutrition. Pavillon Comtols, Université Laval, Québec, Qué, Canada G1K 7P4.

³ Professor (Département de biochimfe) and Director (Centre de recherches sur les maladies lipidiques), Faculté de médecine, Université Laval, Québec, Qué., Canada G1K 7P4.

Manuscript received 31 October 1975.