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Journal of Nutrition Vol. 106 No. 7 July 1976, pp. 884-891
Copyright © 1976 by American Society for Nutrition
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Time Sequence of Lipogenic Changes in Adipose Tissue of Rats when Converted from Ad Libitum Feeding to Meal-Eating1

Michael K. Armstrong, Dale R. Romsos and Gilbert A. Leveille

Department Food Science & Human Nutrition, Michigan State University, East Lansing, Michigan 48824

This study was undertaken to establish the time sequence of lipogenic changes in adipose tissue of rats when converted from ad libitum feeding to meal-eating. Rats were fed a high carbohydrate diet 2 hours/day for 0 to 10 days (meal-eating). The high speed supernatant fraction from homogenized epididymal fat pads was assayed for citrate cleavage enzyme, acetyl CoA carboxylase, fatty acid synthetase and malic enzyme activities. The effects of meal-feeding on in vitro and in vivo rates of fatty acid synthesis in adipose tissue as well as the amounts of glycogen deposited in the adipose tissue were measured. During the first 10 days of meal-feeding, the lipogenic enzyme activities were actually decreased or unchanged in the meal-fed rats but during this time the in vitro and in vivo rates of fatty acid synthesis were progressively increased in the meal-fed rats. Glycogen levels in the adipose tissue of meal-fed rats were greater than the levels in the nibblers. The initial hyperlipogenesis observed in the meal-fed rat appears to be due to changes in substrate uptake by the adipose tissue and/or to alterations in enzyme activation in the adipose tissue rather than to changes in the quantity of enzyme present in the tissue.

KEY WORDS: • meal-eating • lipogenesis • adipose tissue

1 Supported in part by Public Health Services Grants AM 15847 and GM 01818. D.R.R. is a recipient of a Research Career Development Award K04 AM 00112. Michigan Agricultural Experiment Station Journal Article No. 7407.

Manuscript received 26 September 1975.




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