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Duodenal Nutrient Infusion: Effects on Feeding in Intact and Vagotomized Rabbits1

Milan Rezek2 and Donald Novin

Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90024

A comparative study on the satiating effect of duodenal infusions of glycerol, casein and glucose was performed in intact and vagotomized rabbits during both diurnal and nocturnal periods. All duodenally infused substances had satiating effects. Glycerol infusions produced the largest reduction of food intake during the day while casein hydrolysate infusion was most effective in this respect during the night. The most apparent and consistent effect of vagotomy was the elimination of hypophagic effect of diurnal and nocturnal infusions of glucose. Pretreatment with atropine methyl nitrate, which prevented the evoked gastric contractions in response to electrical stimulation of the efferent cervical vagus nerve in acute preparations but did not influence spontaneous intake in free-feeding animals, had no effect on duodenal glucose induced satiety. This result indicates that afferent vagal mediation of information from peripheral metabolic organs is vital to the short-term glucostatic regulation of food intake.

KEY WORDS: • feeding behavior • duodenum • vagotomy • gastric contractions • glucose • glycerol • casein • hypophagia • glucostatic theory

1 Supported by Grant No. NS 7687 from the National Institute of Neurological Diseases and Blindness to D.N. and by the Sellers Foundation.

2 Milan Rezek is now at the Department of Physiology, Faculty of Medicine. University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0W3.

Manuscript received 10 October 1975.




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