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Influence of Dietary Zinc on Lead Toxicity in the Rat¹

Department of Animal Science, Nutritional Biochemistry Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

An investigation of the influence of dietary zinc (8, 35, 200 ppm) on the toxicity of dietary lead (0, 50, 200 ppm) in the young male rat in a seven week period indicated that as dietary zinc increased, the severity of lead toxicity decreased. Evidence included decreased lead concentration in blood, liver, kidneys, and tibias; decreased excretion of urinary delta-aminolevulinic acid; decreased accumulation of free erythrocyte porphyrins; decreased inhibition of kidney delta-aminolevulinic acid dehydrase activity; and a decrease in apparent lead absorption. Injected zinc did not afford protection against lead toxicity. The data indicate that the protective effect of zinc on lead toxicity is largely mediated by an inhibition of lead absorption at the intestinal level.

KEY WORDS: • lead-zinc interaction • tissue lead • lead toxicity

¹ Work supported in part by USPHS Grant GM00658 and the Illinois Agricultural Experiment Station. Data originates from work submitted in partial fulfillment of the requirements for the Doctor of Philosophy at the University of Illinois. Urbana Champaign.

² USPHS Trainee.

³ To whom reprint requests should be sent.

Manuscript received 10 October 1975.

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