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Journal of Nutrition Vol. 106 No. 4 April 1976, pp. 575-579
Copyright © 1976 by American Society for Nutrition
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Effect of Dietary Fat on Fluoride Absorption and Tissue Fluoride Retention in Rats1

E. L. McGown, D. L. Kolstad and J. W. Suttie

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

The effect of dietary fat on fluoride toxicity was investigated in rats fed isoenergetic diets with graded levels of fat (0, 10%, 30% or 50% of energy) containing 400 ppm fluoride. Growth rate was depressed in all groups receiving fluoride but most severely in the 50% dietary fat group. Plasma, liver and femur fluoride concentrations were increased by increasing dietary fat. This was apparently due to increased absorption of fluoride, since urinary fluoride increased and fecal fluoride excretion decreased as fat intake was elevated. The enhancement of fluoride absorption by fat is believed to be due to the delaying effect of fat and fluoride on gastric emptying, thereby allowing more time for the fluoride to be absorbed from the stomach.

KEY WORDS: • fluoride • gastric absorption

1 Research supported by the College of Agricultural and Life Sciences, University of Wisconsin-Madison in part by a research grant from the Aluminum Company of Canada, Aluminum Company of America. Kennecott Copper Corporation, Monsanto Chemical Company. Ormet Corporation, Eastalco Aluminum Company, Kaiser Aluminum and Chemical Corporation, Anaconda Aluminum Company, Martin Marletta. U.S. Steel Corporation, Intalco Aluminum Corporation. National Southwire Aluminum Company, and in part by Grant No. AM-15521 from the National Institutes of Health, U.S. Public Health Service.

Manuscript received 17 October 1975.




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