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Fluoride-Selenium Interaction in the Hard and Soft Tissues of the Rat^1,2,

Division of Nutrition, Department of Biochemistry, School of Dentistry, University of Oregon Health Sciences Center, Portland, Oregon 97201

The interaction of dietary fluoride and selenium in the hard and soft tissues of rats was studied by providing drinking solutions containing 50 ppm F, as NaF, alone or plus 1 or 3 ppm Se as one of the following selenium compounds: NaSeO₃, Na₂SeO₄, DL-selenomethionine, or DL-selenocystine. The following parameters were measured: symptoms of selenium toxicity, soft tissue uptake of fluoride and selenium, histology of liver and kidney tissues, fluoride uptake into growing femur bones, and fluoride uptake onto calcified molar enamel. No evidence was found that fluoride interacted with any of the four selenium compounds.

KEY WORDS: • selenium • fluoride • trace mineralinteraction • bones • teeth • dental caries

¹ A preliminary report was presented at the 59th Annual Meeting of the FASEB (American Institute of Nutrition) in Atlantic City. N.J., on April 17. 1975. and published in abstract form: Federation Proc. 34, 3989 (1975).

² Supported by U.S. Public Health Service Grant DE-03856 from the National Institute of Dental Research.

³ Person to whom reprint requests should be sent.

⁴ Present address: Chemistry Department, University of Sterling, Sterling, Scotland.

Manuscript received 23 September 1975.