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Effect of Dietary Fats on Lipogenesis in Iron Deficiency Anemic Chicks and Rats¹

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115

Chicks and female rats of the Charles River and Buffalo strains were fed diets low in iron which varied in the amount or kind of fat they contained. Iron deficiency was associated with a hyperlipemia in both chicks and rats fed saturated fat (coconut oil). The lipemia did not occur with diets low in fat or those containing safflower oil. Lipogenesis from labeled glucose by the liver was depressed by iron deficiency, particularly in the rats fed the low diet or the diet containing coconut oil. Lipogenesis in the gut was generally elevated in iron deficient rats. Lipogenesis in both liver and gut was substantially higher in rats of the Buffalo strain as compared to the Charles River strain.

KEY WORDS: • iron deficiency anemia • in vitro lipogenesis • dietary fats • strain

¹ Supported in part by Public Health Service Research Grants AM-13090, HE-12399 and K6-AM-18455 from the National Institutes of Health and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health.

² Present address: Living and Learning Center, University of Vermont, Burlington, Vermont.

Manuscript received 21 July 1975.