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Interactions of Trace Metals in Mouse and Rat Tissues; Zinc, Chromium, Copper and Manganese with 13 Other Elements^{* ,1}

Trace Element Laboratory, Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, and Brattleboro Memorial Hospital, Brattleboro, Vermont 05301

Tissues of rats and mice fed a nonessential metal in drinking water for life were analyzed for the essential metals chromium, copper, manganese and zinc. The study involved 505 rats and 843 mice. Livers, lungs, hearts, kidneys and spleens were pooled in groups according to age at death, averaging 5 for rats and 8 for mice, in order to provide adequate sample weight. Copper was significantly higher in livers of rats fed tin, germanium, niobium and zirconium than in controls. Similarly, niobium was associated with deposition of manganese in heart and zinc deposition in liver. Chromium levels were depressed in heart, kidney and spleen by germanium. In mice the greatest effects occurred when indium and rhodium were fed, all four essential trace metals exhibiting raised levels principally in kidney but also in heart and spleen. Chromium levels were raised in all organs but heart when hexavalent chromium was fed. From these data it is apparent that the ingestion of a nonessential metal can enhance the retention of an essential trace metal, perhaps thus avoiding toxicity from the nonessential one.

KEY WORDS: • chromium-6 • germanium • indium • mineral metabolism • nickel • niobium • palladium • rhodium • scandium • tellurium-6 • tin • vanadium • yttrium • zirconium

^* See Naps document # 02736 for two pages of supplementary material (complete bibliography). Order from ASIS/NAPS, c/o Microfiche Publications, 440 Park Avenue South, New York, N.Y. 10016. Remit in advance for each NAPS accession number $1.50 for microfiche or $5.00 for photocopy. Make checks payable to Microfiche Publications. All foreign NAPS requests must include with prepayment a postage and handling fee of $2.00 per photocopy request or $0.50 per microfiche request.

¹ Supported by Public Health Service Research Grant ES 00699-15, Ciba-Geigy Corporation, Cooper Laboratories, Inc., and Foremost-McKesson Foundation, Inc.

² Deceased, April 20, 1975.