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Glucose Antimetabolites and Hunger^*

(Theoretical Article)

Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3 Canada

A decrease in the cellular utilization of glucose produced by several glucose antimetabolites and especially by 2 deoxy-D-glucose considreably stimulates food intake. An analysis of this phenomenon is presented in terms of the available experimental evidence. Experiments in which glucose antimetabolites have been administered so as to influence selectively the central and peripheral glucosensitive loci suggest a possible mechanism for the action of the substances. The mechanisms by which glucose antimetabolites and exogenous insulin induce cellular glucoprivation and the subsequent changes in food intake are compared and discussed.

KEY WORDS: • glucose antimetabolites • hunger • food intake regulation

^* Supported by the Sellers Foundation and the MRC.

Manuscript received 1 May 1975.

This article has been cited by other articles:

				D. Thompson and R. Campbell Hunger in humans induced by 2-deoxy-D-glucose: glucoprivic control of taste preference and food intake Science, December 9, 1977; 198(4321): 1065 - 1068. [Abstract] [PDF]