Journal of Nutrition

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burton, L. E.
Right arrow Articles by Wells, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burton, L. E.
Right arrow Articles by Wells, W. W.

myo-Inositol Metabolism in the Neonatal and Developing Rat Fed a myo-Inositol-free Diet1

Louis E. Burton, Rita E. Ray, James R. Bradford, Joanne P. Orr, Jeffrey A. Nickerson and William W. Wells2

Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824

Neonatal rats of the Holtzman strain, 6 days of age, were fed a myo-inositol restricted liquid formula by gastric intubation for 10 days, after which they were fed a purified myo-inositol-free diet until they were 72 days old. No differences in weight gain were observed between myo-inositol deprived rats and those fed the same diet supplemented with 114 mg myo-inositol/100 ml of formula or 250 mg myo-inositol/100 g diet. Most tissues examined from rats fed the myo-inositol deprived formula and diet had lower free myo-inositol levels than the controls with the exception of the cerebrum and cerebellum. Among those tissues having reduced free myo-inositol levels, the lipid-bound myo-inositol was normal with the exception of the liver. Despite reduced free and lipid-bound myo-inositol in the liver, there was no evidence of fatty liver in the young rats at any age. The cerebrum and cerebellum of myo-inositol deprived rats had normal myelination and mitochondriogenesis as judged by the levels of 2',3'-cyclic nucleotide-3'-phosphohydrolase (EC 3.1.4.1) and fumarase (EC 4.2.1.2) activity, respectively.

KEY WORDS: • myo-inositol deprivation • tissue myo-inositol levels • tissue lipid bound myo-inositol • myelination • mitochondriogenesis

1 This work was supported by Grant HD 06007, U.S. Public Health Service. Michigan Agricultural Experiment Station Journal Article #7587.

2 To whom inquiries should be addressed.

Manuscript received 1 March 1976.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 1976 by American Society for Nutrition